The low-frequency isoform of platelet glycoprotein VIb attenuates ligand-mediated signal transduction but not receptor expression or ligand binding

The 2 most common haplotypes of human GP6, GP6a and GP6b, generate the allelic isoforms glycoprotein VI (GPVI)a and GPVIb that differ by 5 amino acids: S219P, K237E, and T249A in the ectodomains, and Q317L and H322N in the cytoplasmic domain. By quantitative Western blot, we found no association bet...

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Détails bibliographiques
Auteurs principaux: Trifiro, Elisabetta, Williams, Shirley A., Cheli, Yann, Furihata, Kenichi, Pulcinelli, Fabio M., Nugent, Diane J., Kunicki, Thomas J.
Format: Artigo
Langue:Inglês
Publié: American Society of Hematology 2009
Sujets:
Platelets and Thrombopoiesis
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738573/
https://ncbi.nlm.nih.gov/pubmed/19465689
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-209510
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