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FOXO3a Promotes Tumor Cell Invasion through the Induction of Matrix Metalloproteinases

The role of the Forkhead transcription factor FOXO3a in processes that promote tumor metastasis is poorly defined. Here, we show that depletion of FOXO3a from cancer cells leads to decreased tumor size specifically due to attenuated invasive migration. During tumor progression, an increase in tumor...

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Bibliografiske detaljer
Main Authors: Storz, Peter, Döppler, Heike, Copland, John A., Simpson, Kaylene J., Toker, Alex
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738298/
https://ncbi.nlm.nih.gov/pubmed/19564415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00077-09
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