The Flexible Loop of the Human Cytomegalovirus DNA Polymerase Processivity Factor ppUL44 Is Required for Efficient DNA Binding and Replication in Cells

Phosphoprotein ppUL44 of the human cytomegalovirus (HCMV) DNA polymerase plays an essential role in viral replication, conferring processivity to the DNA polymerase catalytic subunit pUL54 by tethering it to the DNA. Here, for the first time, we examine in living cells the function of the highly fle...

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Detalhes bibliográficos
Main Authors: Alvisi, Gualtiero, Roth, Daniela Martino, Camozzi, Daria, Pari, Gregory S., Loregian, Arianna, Ripalti, Alessandro, Jans, David A.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2009
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738227/
https://ncbi.nlm.nih.gov/pubmed/19570866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00669-09
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