Role of Homodimerization of Human Cytomegalovirus DNA Polymerase Accessory Protein UL44 in Origin-Dependent DNA Replication in Cells

The presumed processivity subunit of human cytomegalovirus (HCMV) DNA polymerase, UL44, forms homodimers. The dimerization of UL44 is important for binding to DNA in vitro; however, whether it is also important for DNA replication in a cellular context is unknown. Here we show that UL44 point mutant...

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Detalhes bibliográficos
Main Authors: Sinigalia, Elisa, Alvisi, Gualtiero, Mercorelli, Beatrice, Coen, Donald M., Pari, Gregory S., Jans, David A., Ripalti, Alessandro, Palù, Giorgio, Loregian, Arianna
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2593364/
https://ncbi.nlm.nih.gov/pubmed/18842734
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01193-08
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