Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Virus Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center

Highly pathogenic influenza virus strains currently in circulation pose a significant risk of a global pandemic. Following the reported crystal structure of the endonuclease domain from the avian influenza virus polymerase PA subunit, here we report the results of a systematic X-ray crystallographic...

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Bibliographische Detailangaben
Hauptverfasser: Zhao, Cong, Lou, Zhiyong, Guo, Yu, Ma, Ming, Chen, Yutao, Liang, Shuaiyi, Zhang, Liang, Chen, Shoudeng, Li, Xuemei, Liu, Yingfang, Bartlam, Mark, Rao, Zihe
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2009
Schlagworte:
Structure and Assembly
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738217/
https://ncbi.nlm.nih.gov/pubmed/19587036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00911-09
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