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A Strongly Transdominant Mutation in the Human Immunodeficiency Virus Type 1 gag Gene Defines an Achilles Heel in the Virus Life Cycle

The human immunodeficiency virus type 1 (HIV-1) protease (PR) makes five obligatory cleavages in the viral Gag polyprotein precursor. The cleavage events release the virion structural proteins from the precursor and allow the virion to undergo maturation to become infectious. The protease cleavage b...

詳細記述

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書誌詳細
主要な著者: Lee, Sook-Kyung, Harris, Janera, Swanstrom, Ronald
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology (ASM) 2009
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2738153/
https://ncbi.nlm.nih.gov/pubmed/19515760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00317-09
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