Apurinic/Apyrimidinic Endonuclease 1 Alters Estrogen Receptor Activity and Estrogen-Responsive Gene Expression

Apurinic/apyrimidinic endonuclease 1 or redox factor-1 (Ape1/Ref-1) is a pleiotropic cellular protein involved in DNA repair and, through its redox activity, enhances the binding of a select group of transcription factors to their cognate recognition sequences in DNA. Thus, we were intrigued when we...

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Main Authors: Curtis, Carol D., Thorngren, Daniel L., Ziegler, Yvonne S., Sarkeshik, Ali, Yates, John R., Nardulli, Ann M.
Format: Artigo
Jezik:Inglês
Izdano: The Endocrine Society 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737565/
https://ncbi.nlm.nih.gov/pubmed/19460860
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2009-0093
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