Potent subunit-specific effects on cell growth and drug sensitivity from optimised siRNA-mediated silencing of ribonucleotide reductase

Ribonucleotide reductase (RR) has an essential role in DNA synthesis and repair and is a therapeutic target in a number of different cancers. Previous studies have shown that RNAi-mediated knockdown of either the RRM1 or RRM2 subunit sensitizes cells to the cytotoxic effects of the nucleoside analog...

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Detalhes bibliográficos
Main Authors: Reid, Glen, Wallant, Natacha Coppieters ‘t, Patel, Rachna, Antonic, Ana, Saxon-Aliifaalogo, Faamatala, Cao, Helen, Webster, Gill, Watson, James D
Formato: Artigo
Idioma:Inglês
Publicado em: Library Publishing Media 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737234/
https://ncbi.nlm.nih.gov/pubmed/19771229
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