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Highly Conserved Histidine Plays a Dual Catalytic Role in Protein Splicing: a pK(a) Shift Mechanism
Protein splicing is a precise auto-catalytic process in which an intein excises itself from a precursor with the concomitant ligation of the flanking sequences. Protein splicing occurs through acid-base catalysis in which the ionization states of active site residues are crucial to the reaction mech...
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| Main Authors: | , , , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737186/ https://ncbi.nlm.nih.gov/pubmed/19630416 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja904318w |
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