Decreased TNF-α synthesis by macrophages restricts cutaneous immunosurveillance by memory CD4(+) T cells during aging

Immunity declines during aging, however the mechanisms involved in this decline are not known. In this study, we show that cutaneous delayed type hypersensitivity (DTH) responses to recall antigens are significantly decreased in older individuals. However, this is not related to CC chemokine recepto...

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Detalhes bibliográficos
Main Authors: Agius, Elaine, Lacy, Katie E., Vukmanovic-Stejic, Milica, Jagger, Ann L., Papageorgiou, Anna-Pia, Hall, Sue, Reed, John R., Curnow, S. John, Fuentes-Duculan, Judilyn, Buckley, Christopher D., Salmon, Mike, Taams, Leonie S., Krueger, James, Greenwood, John, Klein, Nigel, Rustin, Malcolm H.A., Akbar, Arne N.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2009
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737169/
https://ncbi.nlm.nih.gov/pubmed/19667063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20090896
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