Population Pharmacokinetic Model of the Pregabalin-Sildenafil Interaction in Rats: Application of Simulation to Preclinical PK-PD Study Design

PURPOSE: Preliminary evidence has suggested a synergistic interaction between pregabalin and sildenafil for the treatment of neuropathic pain. The focus of this study was to determine the influence of sildenafil on the pharmacokinetics (PK) of pregabalin with the objective of informing the design of...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Bender, Gregor, Gosset, James, Florian, Jeff, Tan, Keith, Field, Mark, Marshall, Scott, DeJongh, Joost, Bies, Robert, Danhof, Meindert
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer US 2009
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2737110/
https://ncbi.nlm.nih.gov/pubmed/19669867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11095-009-9942-y
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!

Ejemplares similares