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Altered RNA splicing contributes to skeletal muscle pathology in Kennedy disease knock-in mice
Here, we used a mouse model of Kennedy disease, a degenerative disorder caused by an expanded CAG repeat in the androgen receptor (AR) gene, to explore pathways leading to cellular dysfunction. We demonstrate that male mice containing a targeted Ar allele with 113 CAG repeats (AR113Q mice) exhibit h...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists Limited
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2737058/ https://ncbi.nlm.nih.gov/pubmed/19692580 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.003301 |
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