Replacement of Native Adenovirus Receptor-Binding Sites with a New Attachment Moiety Diminishes Hepatic Tropism and Enhances Bioavailability in Mice

The in vivo efficacy of adenoviral vectors (AdVs) in gene delivery strategies is hampered by the broad tissue tropism of the virus and its efficient binding to human erythrocytes. To circumvent these limitations, we developed a prototype AdV lacking native binding sites. We replaced the adenoviral f...

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Detalhes bibliográficos
Main Authors: Schagen, Frederik H.E., Graat, Harm C.A., Carette, Jan E., Vellinga, Jort, van Geer, Michael A., Hoeben, Rob C., Dermody, Terence S., van Beusechem, Victor W.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2008
Assuntos:
Scientific Papers
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736798/
https://ncbi.nlm.nih.gov/pubmed/18627267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2007.133
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