Selective Deletion of PTEN in Dopamine Neurons Leads to Trophic Effects and Adaptation of Striatal Medium Spiny Projecting Neurons

The widespread distribution of the tumor suppressor PTEN in the nervous system suggests a role in a broad range of brain functions. PTEN negatively regulates the signaling pathways initiated by protein kinase B (Akt) thereby regulating signals for growth, proliferation and cell survival. Pten deleti...

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Main Authors: Diaz-Ruiz, Oscar, Zapata, Agustin, Shan, Lufei, Zhang, YaJun, Tomac, Andreas C., Malik, Nasir, de la Cruz, Fidel, Bäckman, Cristina M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2009
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736587/
https://ncbi.nlm.nih.gov/pubmed/19750226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007027
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