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Early Steps of HIV-1 Fusion Define the Sensitivity to Inhibitory Peptides That Block 6-Helix Bundle Formation
The HIV envelope (Env) glycoprotein mediates membrane fusion through sequential interactions with CD4 and coreceptors, followed by the refolding of the transmembrane gp41 subunit into the stable 6-helix bundle (6HB) conformation. Synthetic peptides derived from the gp41 C-terminal heptad repeat doma...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2009
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| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2736578/ https://ncbi.nlm.nih.gov/pubmed/19763181 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000585 |
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