Insulin crystallization depends on zinc transporter ZnT8 expression, but is not required for normal glucose homeostasis in mice

Zinc co-crystallizes with insulin in dense core secretory granules, but its role in insulin biosynthesis, storage and secretion is unknown. In this study we assessed the role of the zinc transporter ZnT8 using ZnT8-knockout (ZnT8(−/−)) mice. Absence of ZnT8 expression caused loss of zinc release upo...

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Detalhes bibliográficos
Main Authors: Lemaire, K., Ravier, M. A., Schraenen, A., Creemers, J. W. M., Van de Plas, R., Granvik, M., Van Lommel, L., Waelkens, E., Chimienti, F., Rutter, G. A., Gilon, P., Veld, P. A. in't, Schuit, F. C.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736467/
https://ncbi.nlm.nih.gov/pubmed/19706465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0906587106
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