Selective reciprocity in antimicrobial activity versus cytotoxicity of hBD-2 and crotamine

Recent discoveries suggest cysteine-stabilized toxins and antimicrobial peptides have structure–activity parallels derived by common ancestry. Here, human antimicrobial peptide hBD-2 and rattlesnake venom-toxin crotamine were compared in phylogeny, 3D structure, target cell specificity, and mechanis...

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Bibliografiske detaljer
Main Authors: Yount, Nannette Y., Kupferwasser, Deborah, Spisni, Alberto, Dutz, Stephen M., Ramjan, Zachary H., Sharma, Shantanu, Waring, Alan J., Yeaman, Michael R.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736466/
https://ncbi.nlm.nih.gov/pubmed/19706485
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0904465106
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