Cleavage of RseA by RseP requires a carboxyl-terminal hydrophobic amino acid following DegS cleavage

Regulated intramembrane proteolysis (RIP) by the Site-2 protease (S2P) results in the release of a transmembrane signaling protein. Curiously, however, S2P cleavage must be preceded by the action of the Site-1 protease (S1P). To decipher the underlying mechanism, we reconstituted sequential, in vitr...

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Detalhes bibliográficos
Main Authors: Li, Xiaochun, Wang, Boyuan, Feng, Lihui, Kang, Hui, Qi, Yang, Wang, Jiawei, Shi, Yigong
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2009
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736447/
https://ncbi.nlm.nih.gov/pubmed/19706448
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903289106
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