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An Intramolecular Ene Reaction of a Chiral Bicyclic Lactam1
[Image: see text] The preparation of bicylic lactam 2 is described, employing an acetoacetate-based synthesis of 1,4-ketoacid 3. The lactam 2 was shown to undergo a thermal ene reaction at 280–300 °C to afford tricycle 7. Reduction of the ene product followed by removal of the chiral auxiliary fragm...
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| Autors principals: | , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2736314/ https://ncbi.nlm.nih.gov/pubmed/18975907 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jo801696r |
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