Reducing extracellular pH sensitizes the acinar cell to secretagogue-induced pancreatitis responses in rats

BACKGROUND AND AIMS: Protease activation within the pancreatic acinar cell is a key early event in acute pancreatitis and may require low pH intracellular compartments. Clinical studies suggest that acidosis may affect the risk for developing pancreatitis. We hypothesized that exposure to an acid lo...

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Detalhes bibliográficos
Main Authors: Bhoomagoud, Madhavi, Jung, Thomas, Atladottir, Jorunn, Kolodecik, Thomas R, Shugrue, Christine, Chaudhuri, Anamika, Thrower, Edwin C, Gorelick, Fred S
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736307/
https://ncbi.nlm.nih.gov/pubmed/19454288
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1053/j.gastro.2009.05.041
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