Receptors for Tumor Necrosis Factor-α Play a Protective Role against Obesity and Alter Adipose Tissue Macrophage Status

TNF-α signals through two receptors, TNFR1 and TNFR2. Our goals were: 1) determine the role of TNFRs in obesity and metabolic disease and 2) investigate whether TNFRs contribute to the link between obesity and adipose tissue macrophage infiltration and polarization. R1(−/−)R2(−/−) (RKO) and wild-typ...

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Bibliographic Details
Main Authors: Pamir, Nathalie, McMillen, Timothy S., Kaiyala, Karl J., Schwartz, Michael W., LeBoeuf, Renée C.
Format: Artigo
Language:Inglês
Published: The Endocrine Society 2009
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736076/
https://ncbi.nlm.nih.gov/pubmed/19477937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2009-0137
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