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Clinical Grade Ex Vivo-Expanded Human Natural Killer Cells Upregulate Activating Receptors and Death Receptor Ligands and Have Enhanced Cytolytic Activity against Tumor Cells

BACKGROUND: Cancer immunotherapy involving NK-cell infusions and administration of therapeutic agents modulating the susceptibility of tumors to NK-cell lysis has been recently proposed. Here we provide a method to expand highly cytotoxic clinical grade NK cells in vitro for adoptive transfer follow...

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Autores principales: Berg, Maria, Lundqvist, Andreas, McCoy, Philip, Samsel, Leigh, Fan, Yong, Tawab, Abdul, Childs, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2736058/
https://ncbi.nlm.nih.gov/pubmed/19308771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14653240902807034
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