Palmitic acid mediates hypothalamic insulin resistance by altering PKC-θ subcellular localization in rodents

Insulin signaling can be modulated by several isoforms of PKC in peripheral tissues. Here, we assessed whether one specific isoform, PKC-θ, was expressed in critical CNS regions that regulate energy balance and whether it mediated the deleterious effects of diets high in fat, specifically palmitic a...

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Detalhes bibliográficos
Main Authors: Benoit, Stephen C., Kemp, Christopher J., Elias, Carol F., Abplanalp, William, Herman, James P., Migrenne, Stephanie, Lefevre, Anne-Laure, Cruciani-Guglielmacci, Céline, Magnan, Christophe, Yu, Fang, Niswender, Kevin, Irani, Boman G., Holland, William L., Clegg, Deborah J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735917/
https://ncbi.nlm.nih.gov/pubmed/19726875
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI36714
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