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A Cell Surface Inactive Mutant of the Human Lutropin Receptor (hLHR) Attenuates Signaling of Wild-Type or Constitutively Active Receptors via Heterodimerization
The D405N and Y546F mutations of the human lutropin receptor (hLHR) have previously been shown to partially attenuate hCG-stimulated cAMP synthesis despite normal cell surface expression and hCG binding affinity (Min, L. and Ascoli, M. Mol. Endocrinol. 14:1797–1810, 2000). We now show that these mut...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2735609/ https://ncbi.nlm.nih.gov/pubmed/19616090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2009.07.003 |
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