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Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years

Anti-CD3 mAbs may prolong β cell function up to 2 years in patients with new onset Type 1 diabetes (T1DM). A randomized open label trial of anti-CD3 mAb, Teplizumab, in T1DM was stopped after 10 subjects because of increased adverse events than in a previous trial related with higher dosing of drug....

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Dettagli Bibliografici
Autori principali: Herold, Kevan C., Gitelman, Stephen, Greenbaum, Carla, Puck, Jennifer, Hagopian, William, Gottlieb, Peter, Sayre, Peter, Bianchine, Peter, Wong, Emelita, Seyfert-Margolis, Vicki, Bourcier, Kasia, Bluestone, Jeffrey A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735402/
https://ncbi.nlm.nih.gov/pubmed/19443276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.clim.2009.04.007
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