An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection

Hookworms digest hemoglobin from erythrocytes via a proteolytic cascade that begins with the aspartic protease, APR-1. Ac-APR-1 from the dog hookworm, Ancylostoma caninum, protects dogs against hookworm infection via antibodies that neutralize enzymatic activity and interrupt blood-feeding. Toward d...

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Detalhes bibliográficos
Main Authors: Pearson, Mark S., Bethony, Jeffrey M., Pickering, Darren A., de Oliveira, Luciana M., Jariwala, Amar, Santiago, Helton, Miles, Aaron P., Zhan, Bin, Jiang, Desheng, Ranjit, Najju, Mulvenna, Jason, Tribolet, Leon, Plieskatt, Jordan, Smith, Tracey, Bottazzi, Maria Elena, Jones, Kathryn, Keegan, Brian, Hotez, Peter J., Loukas, Alex
Formato: Artigo
Idioma:Inglês
Publicado em: The Federation of American Societies for Experimental Biology 2009
Assuntos:
Research Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735369/
https://ncbi.nlm.nih.gov/pubmed/19380510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-131433
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