An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection

Hookworms digest hemoglobin from erythrocytes via a proteolytic cascade that begins with the aspartic protease, APR-1. Ac-APR-1 from the dog hookworm, Ancylostoma caninum, protects dogs against hookworm infection via antibodies that neutralize enzymatic activity and interrupt blood-feeding. Toward d...

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Main Authors: Pearson, Mark S., Bethony, Jeffrey M., Pickering, Darren A., de Oliveira, Luciana M., Jariwala, Amar, Santiago, Helton, Miles, Aaron P., Zhan, Bin, Jiang, Desheng, Ranjit, Najju, Mulvenna, Jason, Tribolet, Leon, Plieskatt, Jordan, Smith, Tracey, Bottazzi, Maria Elena, Jones, Kathryn, Keegan, Brian, Hotez, Peter J., Loukas, Alex
פורמט: Artigo
שפה:Inglês
יצא לאור: The Federation of American Societies for Experimental Biology 2009
נושאים:
Research Communications
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735369/
https://ncbi.nlm.nih.gov/pubmed/19380510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-131433
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