An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection

Hookworms digest hemoglobin from erythrocytes via a proteolytic cascade that begins with the aspartic protease, APR-1. Ac-APR-1 from the dog hookworm, Ancylostoma caninum, protects dogs against hookworm infection via antibodies that neutralize enzymatic activity and interrupt blood-feeding. Toward d...

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Xehetasun bibliografikoak
Egile Nagusiak: Pearson, Mark S., Bethony, Jeffrey M., Pickering, Darren A., de Oliveira, Luciana M., Jariwala, Amar, Santiago, Helton, Miles, Aaron P., Zhan, Bin, Jiang, Desheng, Ranjit, Najju, Mulvenna, Jason, Tribolet, Leon, Plieskatt, Jordan, Smith, Tracey, Bottazzi, Maria Elena, Jones, Kathryn, Keegan, Brian, Hotez, Peter J., Loukas, Alex
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: The Federation of American Societies for Experimental Biology 2009
Gaiak:
Research Communications
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735369/
https://ncbi.nlm.nih.gov/pubmed/19380510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-131433
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