An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection

Hookworms digest hemoglobin from erythrocytes via a proteolytic cascade that begins with the aspartic protease, APR-1. Ac-APR-1 from the dog hookworm, Ancylostoma caninum, protects dogs against hookworm infection via antibodies that neutralize enzymatic activity and interrupt blood-feeding. Toward d...

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Autores principales: Pearson, Mark S., Bethony, Jeffrey M., Pickering, Darren A., de Oliveira, Luciana M., Jariwala, Amar, Santiago, Helton, Miles, Aaron P., Zhan, Bin, Jiang, Desheng, Ranjit, Najju, Mulvenna, Jason, Tribolet, Leon, Plieskatt, Jordan, Smith, Tracey, Bottazzi, Maria Elena, Jones, Kathryn, Keegan, Brian, Hotez, Peter J., Loukas, Alex
Formato: Artigo
Lenguaje:Inglês
Publicado: The Federation of American Societies for Experimental Biology 2009
Materias:
Research Communications
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735369/
https://ncbi.nlm.nih.gov/pubmed/19380510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-131433
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