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Hypoxia limits antioxidant capacity in red blood cells by altering glycolytic pathway dominance

The erythrocyte membrane is a newly appreciated platform for thiol-based circulatory signaling, and it requires robust free thiol maintenance. We sought to define physiological constraints on erythrocyte antioxidant defense. Hemoglobin (Hb) conformation gates glycolytic flux through the hexose monop...

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Hlavní autoři: Rogers, Stephen C., Said, Ahmed, Corcuera, Daniella, McLaughlin, Dylan, Kell, Pamela, Doctor, Allan
Médium: Artigo
Jazyk:Inglês
Vydáno: The Federation of American Societies for Experimental Biology 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735367/
https://ncbi.nlm.nih.gov/pubmed/19417084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.09-130666
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