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Nitric oxide mediated zinc release contributes to hypoxic regulation of pulmonary vascular tone

The metal binding protein, metallothionein (MT) is a target for NO causing release of bound zinc that affects myogenic reflex in systemic resistance vessels. Here, we investigate a role for NO-induced zinc release in pulmonary vasoregulation. We show that acute hypoxia causes reversible constriction...

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Detalhes bibliográficos
Main Authors: Bernal, Paula J., Leelavanichkul, Karanee, Bauer, Eileen, Cao, Rong, Wilson, Annette, Wasserloos, Karla J., Watkins, Simon C., Pitt, Bruce R., St. Croix, Claudette M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2735130/
https://ncbi.nlm.nih.gov/pubmed/18483408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCRESAHA.108.171264
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