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Constructing bioactive peptides with pH-dependent activities
Many bioactive peptides are featured by their arginine and lysine rich contents. In this study, lysine and arginine residues in lytic peptides were selectively replaced by histidines. Although resulted histidine-containing lytic peptides had decreased activity, they did show pH-dependent cytotoxicit...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2735074/ https://ncbi.nlm.nih.gov/pubmed/19464332 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2009.05.009 |
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