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The role of HER2 in early breast cancer metastasis and the origins of resistance to HER2-targeted therapies
The HER2 gene encodes the receptor tyrosine kinase HER2 and is often over-expressed or amplified in breast cancer. Up-regulation of HER2 contributes to tumor progression. Many aspects of tumor growth are favorably affected through activation of HER2 signaling. Indeed, HER2 plays a role in increasing...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2735009/ https://ncbi.nlm.nih.gov/pubmed/19450579 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.yexmp.2009.05.001 |
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