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SIRT1 and Caloric Restriction: An Insight Into Possible Trade-Offs Between Robustness and Frailty
PURPOSE OF REVIEW: This review aims to summarize the importance of the mammalian NAD-dependent deacetylase SIRT1 as a critical mediator that coordinates metabolic responses to caloric restriction (CR) and the recent progress in the development of SIRT1-targeted CR mimetics. It also discusses possibl...
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2734391/ https://ncbi.nlm.nih.gov/pubmed/19474721 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/MCO.0b013e32832c932d |
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