Loss of Cardiac Phosphoinositide 3-kinase p110α Results in Contractile Dysfunction: Lu et al PI3K p110α Regulates Myocyte Contractility

BACKGROUND: Phosphoinositide 3-kinase (PI3K) p110α plays a key role in insulin action and tumorigenesis. Myocyte contraction is initiated by an inward Ca(2+) current (I(Ca,L)) through the voltage-dependent L-type Ca(2+) channel (LTCC). The aim of this study was to evaluate if p110α also controls car...

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Main Authors: Lu, Zhongju, Jiang, Ya-Ping, Wang, Wei, Xu, Xin-Hua, Mathias, Richard T., Entcheva, Emilia, Ballou, Lisa M., Cohen, Ira S., Lin, Richard Z.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2734096/
https://ncbi.nlm.nih.gov/pubmed/19597047
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.109.873380
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