Leptin Administration Favors Muscle Mass Accretion by Decreasing FoxO3a and Increasing PGC-1α in ob/ob Mice

Absence of leptin has been associated with reduced skeletal muscle mass in leptin-deficient ob/ob mice. The aim of our study was to examine the effect of leptin on the catabolic and anabolic pathways regulating muscle mass. Gastrocnemius, extensor digitorum longus and soleus muscle mass as well as f...

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Main Authors: Sáinz, Neira, Rodríguez, Amaia, Catalán, Victoria, Becerril, Sara, Ramírez, Beatriz, Gómez-Ambrosi, Javier, Frühbeck, Gema
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2009
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2733298/
https://ncbi.nlm.nih.gov/pubmed/19730740
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0006808
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