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Structural waters define a functional channel mediating activation of the GPCR, rhodopsin
Structural water molecules may act as prosthetic groups indispensable for proper protein function. In the case of allosteric activation of G protein-coupled receptors (GPCRs), water likely imparts structural plasticity required for agonist-induced signal transmission. Inspection of structures of GPC...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2732891/ https://ncbi.nlm.nih.gov/pubmed/19706523 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0901074106 |
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