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Conserved waters mediate structural and functional activation of family A (rhodopsin-like) G protein-coupled receptors

G protein-coupled receptors with seven transmembrane α-helices (GPCRs) comprise the largest receptor superfamily and are involved in detecting a wide variety of extracellular stimuli. The availability of high-resolution crystal structures of five prototypical GPCRs, bovine and squid rhodopsin, engin...

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Bibliografske podrobnosti
Main Authors: Angel, Thomas E., Chance, Mark R., Palczewski, Krzysztof
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2009
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2688986/
https://ncbi.nlm.nih.gov/pubmed/19433801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903545106
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