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In vivo manipulation of gene expression in non-human primates using lentiviral vectors as delivery vehicles

Nonhuman primates (NHPs) are an invaluable resource for the study of genetic regulation of disease mechanisms. The main disadvantage of using NHPs as a preclinical model of human disease is the difficulty of manipulating the monkey genome using conventional gene modifying strategies. Lentiviruses of...

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Hlavní autoři: Dissen, Gregory A., Lomniczi, Alejandro, Neff, Tanaya L., Hobbs, Theodore R., Kohama, Steven G., Kroenke, Christopher D., Galimi, Francesco, Ojeda, Sergio R.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732747/
https://ncbi.nlm.nih.gov/pubmed/19559089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ymeth.2009.06.004
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