Human genetic deficiencies reveal the roles of complement in the inflammatory network: Lessons from nature

Complement component C5 is crucial for experimental animal inflammatory tissue damage; however, its involvement in human inflammation is incompletely understood. The responses to Gram-negative bacteria were here studied taking advantage of human genetic complement-deficiencies—nature's own knoc...

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Bibliographic Details
Main Authors: Lappegård, Knut Tore, Christiansen, Dorte, Pharo, Anne, Thorgersen, Ebbe Billmann, Hellerud, Bernt Christian, Lindstad, Julie, Nielsen, Erik Waage, Bergseth, Grethe, Fadnes, Dag, Abrahamsen, Tore G., Høiby, E. Arne, Schejbel, Lone, Garred, Peter, Lambris, John D., Harboe, Morten, Mollnes, Tom Eirik
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 2009
Subjects:
Biological Sciences
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732707/
https://ncbi.nlm.nih.gov/pubmed/19717455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0903613106
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