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The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics

Mutations in parkin, PTEN-induced kinase 1 (PINK1) and DJ-1 can all cause autosomal recessive forms of Parkinson disease. Recent data suggest that these recessive parkinsonism-associated genes converge within a single pathogenic pathway whose dysfunction leads to the loss of substantia nigra pars co...

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Detalhes bibliográficos
Main Authors: Thomas, Kelly Jean, Cookson, Mark R.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732569/
https://ncbi.nlm.nih.gov/pubmed/19703660
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biocel.2009.02.018
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