G Protein-Coupled Receptor 39 Deficiency Is Associated with Pancreatic Islet Dysfunction

G protein-coupled receptor (GPR)-39 is a seven-transmembrane receptor expressed mainly in endocrine and metabolic tissues that acts as a Zn(++) sensor signaling mainly through the G(q) and G(12/13) pathways. The expression of GPR39 is regulated by hepatocyte nuclear factor (HNF)-1α and HNF-4α, and i...

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Main Authors: Holst, Birgitte, Egerod, Kristoffer L., Jin, Chunyu, Petersen, Pia Steen, Østergaard, Mette Viberg, Hald, Jacob, Sprinkel, A. M. Ejernaes, Størling, Joachim, Mandrup-Poulsen, Thomas, Holst, Jens J., Thams, Peter, Ørskov, Cathrine, Wierup, Nils, Sundler, Frank, Madsen, Ole D., Schwartz, Thue W.
Format: Artigo
Sprog:Inglês
Udgivet: The Endocrine Society 2009
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732286/
https://ncbi.nlm.nih.gov/pubmed/19213833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2008-1250
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