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Predicting gene targets of perturbations via network-based filtering of mRNA expression compendia
Motivation: DNA microarrays are routinely applied to study diseased or drug-treated cell populations. A critical challenge is distinguishing the genes directly affected by these perturbations from the hundreds of genes that are indirectly affected. Here, we developed a sparse simultaneous equation m...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2732281/ https://ncbi.nlm.nih.gov/pubmed/18779235 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btn476 |
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