A probe-density-based analysis method for array CGH data: simulation, normalization and centralization

Motivation: Genomic instability is one of the fundamental factors in tumorigenesis and tumor progression. Many studies have shown that copy-number abnormalities at the DNA level are important in the pathogenesis of cancer. Array comparative genomic hybridization (aCGH), developed based on expression...

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Main Authors: Chen, Hung-I Harry, Hsu, Fang-Han, Jiang, Yuan, Tsai, Mong-Hsun, Yang, Pan-Chyr, Meltzer, Paul S., Chuang, Eric Y., Chen, Yidong
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2008
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Original Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2732214/
https://ncbi.nlm.nih.gov/pubmed/18603568
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btn321
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