Human Dendritic Cells Induce the Differentiation of Interleukin-21-producing T Follicular Helper-like Cells through Interleukin-12

SUMMARY: T follicular helper (Tfh) cells help development of antibody responses via Interleukin-21 (IL-21). Here we show that activated human dendritic cells (DCs) induced naïve CD4(+) T cells to become IL-21-producing Tfh-like cells through IL-12. CD4(+) T cells primed with IL-12 induced B cells to...

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Detalhes bibliográficos
Main Authors: Schmitt, Nathalie, Morita, Rimpei, Bourdery, Laure, Bentebibel, Salah Eddine, Zurawski, Sandra M., Banchereau, Jacques, Ueno, Hideki
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731623/
https://ncbi.nlm.nih.gov/pubmed/19592276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2009.04.016
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