Spread of Infection and Lymphocyte Depletion in Mice Depends on Polymerase of Influenza Virus

SC35M is a mouse-adapted variant of the highly pathogenic avian influenza virus SC35. We have previously shown that interspecies adaptation is mediated by mutations in the viral polymerase and that it is paralleled by the acquisition of high pathogenicity for mice. In the present study, we have comp...

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Bibliographic Details
Main Authors: Gabriel, Gülsah, Klingel, Karin, Planz, Oliver, Bier, Katja, Herwig, Astrid, Sauter, Martina, Klenk, Hans-Dieter
Format: Artigo
Language:Inglês
Published: American Society for Investigative Pathology 2009
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Regular Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731136/
https://ncbi.nlm.nih.gov/pubmed/19700749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2353/ajpath.2009.090339
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