Modification of a loop sequence between α-helices 6 and 7 of virus capsid (CA) protein in a human immunodeficiency virus type 1 (HIV-1) derivative that has simian immunodeficiency virus (SIVmac239) vif and CA α-helices 4 and 5 loop improves replication in cynomolgus monkey cells

BACKGROUND: Human immunodeficiency virus type 1 (HIV-1) productively infects only humans and chimpanzees but not cynomolgus or rhesus monkeys while simian immunodeficiency virus isolated from macaque (SIVmac) readily establishes infection in those monkeys. Several HIV-1 and SIVmac chimeric viruses h...

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Bibliographic Details
Main Authors: Kuroishi, Ayumu, Saito, Akatsuki, Shingai, Yasuhiro, Shioda, Tatsuo, Nomaguchi, Masako, Adachi, Akio, Akari, Hirofumi, Nakayama, Emi E
Format: Artigo
Language:Inglês
Published: BioMed Central 2009
Subjects:
Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2731049/
https://ncbi.nlm.nih.gov/pubmed/19650891
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-4690-6-70
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