p53/CEP-1 Increases or Decreases Lifespan, Depending on Level of Mitochondrial Bioenergetic Stress

Mitochondrial pathologies underlie a number of life-shortening diseases in humans. In the nematode Caenorhabditis elegans, severely reduced expression of mitochondrial proteins involved in electron transport chain-mediated energy production also leads to pathological phenotypes, including arrested d...

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Huvudupphovsmän: Ventura, Natascia, Rea, Shane L., Schiavi, Alfonso, Torgovnick, Alessandro, Testi, Roberto, Johnson, Thomas E.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2009
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730656/
https://ncbi.nlm.nih.gov/pubmed/19416129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1474-9726.2009.00482.x
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