DIVERGENT TNF RECEPTOR-RELATED REMODELING RESPONSES IN HEART FAILURE: Role of NF-κB and Inflammatory Activation

BACKGROUND: Although pre-clinical data suggested that tumor necrosis factor-α (TNF) neutralization in heart failure (HF) would be beneficial, clinical trials of TNF antagonists were paradoxically negative. We hypothesized that TNF induces opposing inflammatory and remodeling responses in HF that are...

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מידע ביבליוגרפי
Main Authors: Hamid, Tariq, Gu, Yan, Ortines, Roger V., Bhattacharya, Chhandashri, Wang, Guangwu, Xuan, Yu-Ting, Prabhu, Sumanth D.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2009
נושאים:
Article
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730645/
https://ncbi.nlm.nih.gov/pubmed/19255345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.108.802918
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