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Tumor suppressor and oncogene actions of TGFβ1 occur early in skin carcinogenesis and are mediated by Smad3

Interactions between TGFβ1 and ras signaling pathways play an important role in cancer development. Here we show that in primary mouse keratinocytes, v-ras(Ha) does not block the early biochemical events of TGFβ1 signal transduction but does alter global TGFβ1 mediated gene expression in a gene spec...

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Autors principals: Bae, Dong-Soon, Blazanin, Nicholas, Licata, Mathew, Lee, Jessica, Glick, Adam B.
Format: Artigo
Idioma:Inglês
Publicat: 2009
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730634/
https://ncbi.nlm.nih.gov/pubmed/18942075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/mc.20482
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