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Crosstalk between Aurora-A and p53: Frequent Deletion or Downregulation of Aurora-A in Tumors from p53 Null Mice

SUMMARY: The Aurora-A kinase gene is amplified in a subset of human tumors and in radiation-induced lymphomas from p53 heterozygous mice. Normal tissues from p53(−/−) mice have increased Aurora-A protein levels, but lymphomas from these mice exhibit heterozygous deletions of Aurora-A and/or reduced...

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Bibliografiske detaljer
Main Authors: Mao, Jian-Hua, Wu, Di, Perez-Losada, Jesus, Jiang, Tao, Li, Qian, Neve, Richard M., Gray, Joe W., Cai, Wei-Wen, Balmain, Allan
Format: Artigo
Sprog:Inglês
Udgivet: 2007
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730519/
https://ncbi.nlm.nih.gov/pubmed/17292827
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccr.2006.11.025
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