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Identification of the Cu(II) Coordinating Residues in the Prion Protein by Metal-Catalyzed Oxidation Mass Spectrometry: Evidence for Multiple Isomers at Low Cu(II) Loadings

While the Cu(II) binding sites of the prion protein have been well studied under Cu-saturation conditions, the identity of the residues involved in coordinating Cu(II) at low stoichiometries and the order in which the binding sites load with Cu(II), remain unresolved. In this study, we have used two...

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主要な著者: Srikanth, Rapole, Wilson, Jonathan, Burns, Colin S., Vachet, Richard W.
フォーマット: Artigo
言語:Inglês
出版事項: 2008
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2730420/
https://ncbi.nlm.nih.gov/pubmed/18690704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi800970m
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