O-Antigen Delays Lipopolysaccharide Recognition and Impairs Antibacterial Host Defense in Murine Intestinal Epithelial Cells

Although Toll-like receptor (TLR) 4 signals from the cell surface of myeloid cells, it is restricted to an intracellular compartment and requires ligand internalization in intestinal epithelial cells (IECs). Yet, the functional consequence of cell-type specific receptor localization and uptake-depen...

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Detalhes bibliográficos
Main Authors: Duerr, Claudia U., Zenk, Sebastian F., Chassin, Cécilia, Pott, Johanna, Gütle, Dominique, Hensel, Michael, Hornef, Mathias W.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2009
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2729928/
https://ncbi.nlm.nih.gov/pubmed/19730692
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1000567
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